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KMID : 0370220190630010037
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Yakhak Hoeji
2019 Volume.63 No. 1 p.37 ~ p.42
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Effect of C-terminal Amidated Tight Junction Modulator and Fructose Polymer on the Nasal and Intestinal Permeation of Atenolol
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Song Keon-Hyoung
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Abstract
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Zonula occludens toxin has been shown to reversibly open tight junctions in endothelial and epithelial cells. The purpose of this study was to evaluate the permeation activity of C-terminal amidated fragment of Zonula occludens toxin and co-administration with a fructose polymer on enhancing the nasal and duodenal administration of atenolol. The C-terminal amidated peptide (Phe-Cys-Ile-Gly-Arg-Leu-NH2) resulted in statistically significant improvement in permeation of atenolol compared to the control in both nasal and duodenal administration. Also, the permeability enhancing effect of the C-terminal amidated peptide was significantly promoted by the fructose polymer, levan. C-terminal amidated peptide together with the addition of levan may be promising as a tight junction modulated permeation enhancer, and allow the development of the mucosal drug delivery of low bioavailability therapeutic agents.
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KEYWORD
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Tight junction modulator, C-terminal amidation, fructose polymer, atenolol
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